| 產(chǎn)品編號(hào) | bs-0066R |
| 英文名稱 | TGF alpha Rabbit pAb |
| 中文名稱 | 轉(zhuǎn)移生長(zhǎng)因子α抗體 |
| 別 名 | EGF like TGF; ETGF; TFGA; TGF A; TGF type 1; TGFA; Transforming growth factor alpha; Transforming growth factor alpha precursor; Wa1; Waved 1; TGFA_HUMAN; TGFα; TGF-α; TGF α. |
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Specific References (1) | bs-0066R has been referenced in 1 publications.
[IF=5.17] Sun et al. The correlation between microRNA490-3p and TGFα in endometrial carcinoma tumorigenesis and progression. (2016) Oncotarge. 7:9236-49 WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 心血管 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素 細(xì)胞因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 17 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse TGF-alpha |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar (By similarity). Inhibitor of acid secretion. Inhibitor of aminopyrine uptake in parietal cells (in vitro). Subunit: Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. Subcellular Location: Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. Similarity: Contains 1 EGF-like domain. SWISS: P48030 Gene ID: 21802 Database links: Entrez Gene: 7039 Human Entrez Gene: 21802 Mouse Omim: 190170 Human SwissProt: P01135 Human SwissProt: P48030 Mouse Unigene: 170009 Human Unigene: 137222 Mouse Unigene: 9952 Rat 生長(zhǎng)因子和激素 TGFα是一個(gè)強(qiáng)有力的只有絲分裂多肽,主要由惡性腫瘤產(chǎn)生。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Kidney tissue lysates
Lane 2: Mouse Colon tissue lysates
Lane 3: Mouse Spleen tissue lysates
Lane 4: Rat Kidney tissue lysates
Lane 5: Rat Liver tissue lysates
Lane 6: Rat Spleen tissue lysates
Lane 7: Human Jurkat cell lysates
Lane 8: Human THP-1 cell lysates
Lane 9: Human A431 cell lysates
Lane 10: Human HepG2 cell lysates
Lane 11: Human MCF-7 cell lysates
Lane 12: Human U87MG cell lysates
Primary: Anti- TGF alpha (bs-0066R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 17 kDa
Observed band size: 15 kDa
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