| 產(chǎn)品編號(hào) | bs-23205R |
| 英文名稱 | C Peptide (mouse) Rabbit pAb |
| 中文名稱 | 小鼠C-肽抗體 |
| 別 名 | proinsulin precursor; Hyperproinsulinemia; INS; Insulin Precursor; IRDN; Proinsulin; Propeptide; C-Peptide; INS2_MOUSE. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 生長因子和激素 糖尿病 細(xì)胞因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Mouse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 3 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse C Peptide: 57-87/110 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
C Peptide is part of the molecule of Proinsulin, that consists of three parts: C Peptide and two long strands of amino acids (called the alpha and beta chains) that later become linked together to form the insulin molecule. From every molecule of proinsulin, one molecule of insulin plus one molecule of C Peptide are produced. C peptide is released into the blood stream in equal amounts to insulin. A test of C peptide levels will show how much insulin the body is making. Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds. Subcellular Location: Secreted. Similarity: Belongs to the insulin family. Database links: Entrez Gene: 3630 Human Entrez Gene: 16334 Mouse Omim: 176730 Human SwissProt: P01308 Human SwissProt: P01326 Mouse Unigene: 272259 Human C肽是胰島β細(xì)胞的分泌產(chǎn)物，與大、小鼠有部分交叉，它與胰島素有一個(gè)共同的前體——胰島素原 C肽是連接肽，因?yàn)樽畛跛沁B接A、B兩條鏈的中間段，胰島素原分解后才能獨(dú)立存在，它也能從細(xì)胞釋放到血液中。因此，從胰島細(xì)胞分泌入血的主要成分有兩種，一種是人們所熟悉的胰島素，另一種就是C肽。 近年來，隨著深入的研究，發(fā)現(xiàn)C肽是具有生物學(xué)活性的。并且，這種生物學(xué)活性對(duì)于延緩糖尿病慢性并發(fā)癥的發(fā)生和發(fā)展可能具有重要的作用. |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (rat pancreas); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (C Peptide) Polyclonal Antibody, Unconjugated (bs-23205R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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