精品国产av自拍_精品日韩欧美在线视频一区二区_一区二区在线观看在线_福利在线观看免费高清完整版_无码免费动漫老黄网站_无码一区在线观看视频_精品五月精品婷婷_免费国产日本高清_亚洲特黄特色一级在线观看_国产Ⅴ亚洲Ⅴ欧美Ⅴ专区

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美四虏免费一级成人片,久久国内免费视频,男女性爽大片在线观看
Rabbit Anti-Tsg101/PE-Cy5.5 Conjugated antibody (bs-1365R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1365R-PE-Cy5.5
英文名稱 Rabbit Anti-Tsg101/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的腫瘤易感基因101蛋白抗體
別    名 ESCRT I complex subunit TSG101; ESCRT-I complex subunit TSG101; Tsg101; TSG 10; TSG 101; TSG10; Tumor susceptibility gene 10; Tumor susceptibility gene 101; Tumor susceptibility gene 101 protein; Tumor susceptibility protein; Tumor susceptibility protein isoform 3; VPS 23; VPS23; TS101_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  微生物學(xué)  細(xì)胞分化  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Tsg101 N-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. TSG101 also interacts with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses like HIV-1 p6, human spumavirus Gag, HTLV-1 Gag, as well as of Ebolavirus VP40.

Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.

Subunit:
Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and a FAM125/MVB12 protein (FAM125A or -B) in a 1:1:1:1 stoechiometry. Interacts with VPS37A, VPS37B and VPS37C. Interacts with ubiquitin, stathmin, GMCL, DMAP1 and AATF (By similarity). Interacts with HGS; the interaction mediates the association with the ESCRT-0 complex. Interacts with GGA1 and GGA3. Interacts (via UEV domain) with PDCD6IP/AIP1. Interacts with VPS28, SNF8 and VPS36. Self-associates. Interacts with FAM125A/MVB12A; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with CEP55; the interaction is required for cytokinesis but not for viral budding. Interacts with PDCD6. Interacts with HIV-1 p6. Interacts with human spumavirus Gag. Interacts with HTLV-1 Gag. Interacts with Ebola virus VP40. Interacts with EIAV p9; the interaction has been shown in vitro. Interacts with MGRN1.

Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.

Tissue Specificity:
Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.

Post-translational modifications:
Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1.

Similarity:
Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
Contains 1 SB (steadiness box) domain.
Contains 1 UEV (ubiquitin E2 variant) domain.

Database links:

Entrez Gene: 7251 Human

Entrez Gene: 22088 Mouse

Entrez Gene: 292925 Rat

Omim: 601387 Human

SwissProt: Q99816 Human

SwissProt: Q61187 Mouse

SwissProt: Q6IRE4 Rat

Unigene: 523512 Human

Unigene: 241334 Mouse

Unigene: 7410 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 0592123.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
苍井空毛片精品久久久 | 欧美成人免费全部观看国产 | 成年免费视频播放网站推荐 | 日韩福利视频精品专区 | 欧美午夜精品一区区电影 | 欧美激情二区三区 | 亚洲第一成年人网站 | 无码毛片内射白浆视频 | 亚洲欧洲另类春色校园小说 | 亚洲av成人精品一区二区三区 | 日日噜噜噜夜夜爽爽狠狠 | 精品美模顾欣欣无圣光 | 么公又大又硬又粗又长 | 日韩国产免费一区二区三区 | 六月婷婷国产精品综合 | 久久综合给合久久狠狠狠97色 | 午夜美女福利视频 | 先峰中文字幕一二三区 | 久久91精品国产91久 | 国产91麻豆免费观看 | 欧美人与动牲性行为视频 | 少妇高潮一区二区三区99 | 亚洲国产AAA毛片无费看 | 国产在线播放91 | 久草国产在线播放 | 国产欧美日韩综合一区在线播放 | 精品国产aⅴ无码一区二区91 | 顶级少妇AAAAABBBBB片 | 视频在线观看一区 | 亚洲AV成人一区二区三区在线观看 | 色狠狠久久AV北条麻妃 | 精品精品国产高清A毛片 | 国产精品美女www爽爽爽 | 国产成人一区二区三中文 | 亚洲AV中文无码伦在线亚洲 | 欧美精品一区二区三区中 | 精品亚洲一区二区在线播放 | 国产亚洲午夜精品a一区二区 | 中文字幕乱码高清免费网 | 2019国自产拍精品 | aaa在线观看视频高清视频 |